Decrypting a collagen's role in schizophrenia
A small peptide generated from a collagen protein may protect the brain from schizophrenia by promoting the formation of neuronal synapses, according to a paper published in The Journal of Cell...
View ArticleCancer cells remodel their environment to make it easier to reach nearby...
A new study from MIT reveals how cancer cells take some of their first steps away from their original tumor sites. This spread, known as metastasis, is responsible for 90 percent of cancer deaths.
View ArticleWaist-to-height ratio should be used as a screening tool for early health risks
Waist-to-height ratio is a simpler and more predictive indicator of the 'early heath risks' associated with central obesity than the complex 'matrix', based on BMI and waist circumference (WC),...
View ArticleAmerican doctors make new esophagus using stents and skin
American doctors have made a new esophagus for a young man, using donated skin tissue and metal stents, in the latest example of scientists creating body parts in the lab to help patients with few...
View ArticleAnti-fibrotic peptide shows early promise against interstitial lung disease
The results of preclinical studies by investigators at the Medical University of South Carolina (MUSC) reported in the April 2016 issue of Translational Research suggest that the M10 peptide could help...
View ArticleMeaning of brain scans for 'pain' called into question
Patterns of brain activity thought to show pain responses have been called into question after researchers from UCL and the University of Reading saw such patterns in rare patients born without a sense...
View ArticleThree-dimensional model sheds light into the synergy between cell...
The fight against deadly forms of brain cancer, such as glioblastoma, could soon benefit from a major breakthrough, thanks to A*STAR researchers. The team has found a new link between cancer cell...
View ArticleResearchers first to grow living bone that replicates original anatomical...
A new technique developed by Gordana Vunjak-Novakovic, the Mikati Foundation Professor of Biomedical Engineering at Columbia Engineering and professor of medical sciences (in Medicine) at Columbia...
View ArticleStudy links two genes to breast cancer survival
Testing for the activity of two genes could pick out women who are at increased risk of dying from their breast cancers, suggests a new study of almost 2,000 patients.
View ArticleStudy identifies possible mechanism for resistance to antiangiogenesis therapy
Massachusetts General Hospital (MGH) investigators have identified a potential mechanism behind the resistance that inevitably develops to cancer treatment with a combination of chemotherapy and...
View ArticleStudy links changes in collagen to worse pancreatic cancer prognosis
A study in the current journal Oncotarget provides the first evidence linking a disturbance of the most common protein in the body with a poor outcome in pancreatic cancer.
View ArticleCancer cells 'talk' to their environment, and it talks back
Interactions between an animal cell and its environment, a fibrous network called the extracellular matrix, play a critical role in cell function, including growth and migration. But less understood is...
View ArticleTissue engineering advance reduces heart failure in model of heart attack
Researchers have grown heart tissue by seeding a mix of human cells onto a 1-micron-resolution scaffold made with a 3-D printer. The cells organized themselves in the scaffold to create engineered...
View ArticleNew technology to speed up testing of cancer drugs
A new technology that could speed up the testing of drugs and reduce the use of animals in the lab has been developed by scientists at The University of Nottingham.
View ArticleChanging the environment within bone marrow alters blood cell development
Researchers at the University of Illinois report they can alter blood cell development through the use of biomaterials designed to mimic characteristics of the bone marrow.
View ArticleCancer cells hijack healthy cells to help them spread to other organs
An interaction between two proteins enables cancer cells to use the physical forces of healthy cells to start spreading to other parts of the body.
View ArticleChanges of the cell environment are associated with certain eye diseases
Ischemic disorders of the retina are a frequent cause of blindness. The surrounding cellular protein scaffold might play a crucial role in this process.
View ArticleNew understanding of chronic lung inflammatory diseases unfolding
Researchers studying chronic inflammation that can lead to the development of lung diseases such as asthma, pulmonary fibrosis, and cancer, are focusing on the role cytokines play in regulating the...
View ArticleScientific discovery opens new possibilities for cancer and fibrosis treatment
Researchers from the Turku Centre for Biotechnology (BTK) in Finland have discovered that a cellular fuel sensor, known to control energy processes in the cells, is involved in the regulation of the...
View ArticleNew gelatin devices that imitate the activity of the body in bone regeneration
Regenerative medicine is a discipline that is continually growing and encompasses a whole arsenal of therapeutic strategies, from recombinant proteins and stem cells right up to materials and matrices...
View ArticleEngineers show key feature for modeling how cells spread in fibrous environments
One area of research within mechanobiology, the study of how physical forces influence biological processes, is on the interplay between cells and their environment and how it impacts their ability to...
View ArticleResearchers develop new technique to unveil 'matrix' inside tissues and tumours
Scientists from the Biotech Research & Innovation Centre (BRIC) at the University of Copenhagen have developed a groundbreaking method to reveal the structure of tissues and tumours with...
View ArticleTears in tiny bone cells called osteocytes appear an important step to better...
The force gravity and physical activity put on our bones causes tiny tears in the membranes of the tiny cells that enable us to make or break down bone, scientists say.
View ArticleResearchers identify genes fueling neuroblastoma spread
For the first time, Mayo Clinic researchers and colleagues present data on how nervous system tumors, called neuroblastomas, spread. Their paper, published in Cancer Cell, clarifies the relationship...
View ArticleNew treatment significantly improved bladder activity after spinal cord injury
Researchers have shown that compared to placebo, a drug treatment intended to prevent remodeling of the bladder wall and given within 48 hours after spinal cord injury (SCI) in dogs was associated with...
View ArticleHow deep can a cell sense
National University of Singapore researchers discovered that mechanical cues from the porous microenvironment of the bone matrix could affect the proliferation of cancer cells.
View ArticleChemo-loaded nanoparticles target breast cancer that has spread to bone
Breast cancer that spreads often infiltrates bone, causing fractures and intense pain. In such cases, chemotherapy is ineffective because the environment of the bone protects the tumor, even as the...
View ArticleNovel platform for investigating quiescence in dormancy-capable cancer cells
A team of researchers from the University of Minnesota-Twin Cities has reported a novel encapsulation approach in identifying dormant cancer cells and maintaining them in a quiescent state. Their...
View ArticleSynthetic hydrogels deliver cells to repair intestinal injuries
By combining engineered polymeric materials known as hydrogels with complex intestinal tissue known as organoids - made from human pluripotent stem cells - researchers have taken an important step...
View ArticleAntibiotic ciprofloxacin increases risk of tears and rupture in mouse aortas
A team of researchers at Baylor College of Medicine, the Texas Heart Institute and Baylor College of Medicine's Cardiovascular Research Institute has found that ciprofloxacin, a widely prescribed...
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