A team of researchers at Baylor College of Medicine, the Texas Heart Institute and Baylor College of Medicine's Cardiovascular Research Institute has found that ciprofloxacin, a widely prescribed antibiotic, increases the risk of tears and rupture on the main artery of the body, the aorta, in a mouse model of human aortic aneurysms and dissections (AAD), a disease that carries high risk of death from aortic rupture. The study, which is presented today at the American Heart Association Scientific Sessions 2017, provides insights into the biological mechanism underlying the antibiotic's effects on aortic tissue and suggests that the drug should be used with caution in patients with aortic dilatation.
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